tag:blogger.com,1999:blog-8480427453110572235.post7672354318838280237..comments2010-02-10T06:35:24.285+11:00Danielhttp://www.blogger.com/profile/07276690118219000204noreply@blogger.comBlogger12125tag:blogger.com,1999:blog-8480427453110572235.post-63987837836331152382010-02-10T06:35:24.285+11:002010-02-10T06:35:24.285+11:00I agree with the test results being free. (as in the other companies that are offering results for free.) Is the personalized genomics article you&#39;re talking about on NY times online or is it only on the paper version?***Anomaly1765http://www.blogger.com/profile/17001363743050195595noreply@blogger.comtag:blogger.com,1999:blog-8480427453110572235.post-41313018183634745232008-04-16T09:37:00.000+10:002008-04-16T09:37:00.000+10:00Hi Steve,<BR/><BR/>The only NY Times article on personal genomics I read on Sunday was <A HREF="http://www.nytimes.com/2008/04/13/nyregion/13dna.html?_r=1&ref=nyregion&oref=slogin" REL="nofollow">this one on Navigenics</A> - nothing about 23andMe in there. Do you have a link to the story you're thinking of?Danielhttp://www.blogger.com/profile/07276690118219000204noreply@blogger.comtag:blogger.com,1999:blog-8480427453110572235.post-22960130676794981852008-04-16T09:26:00.000+10:002008-04-16T09:26:00.000+10:00Did you read the NY Times on Sunday?<BR/>Pretty harsh on 23andMe...they sounded like the Sherpa.<BR/>www.thegenesherpa.blogspot.comSteve Murphy MDhttp://www.blogger.com/profile/11774190000307343476noreply@blogger.comtag:blogger.com,1999:blog-8480427453110572235.post-86194451314097046862008-04-14T09:22:00.000+10:002008-04-14T09:22:00.000+10:00Hi James,<BR/><BR/>I agree - I've <A HREF="http://www.genetic-future.com/2008/04/height-and-hypertension-genes-in-nature.html" REL="nofollow">previously discussed</A> the difficulties associated with determining the genetics of height. IQ looks as though it will also be difficult to pin down genetically, although it hasn't yet been subjected to sufficiently large genome-wide scans to know for sure.<BR/><BR/>This is probably largely a technical issue: current scans are only really able to detect common, simple genetic variations. Once cheap large-scale sequencing comes on-line we will have a much greater capacity to survey the other types of variation (e.g. rare variants and large copy-number variations). This will bring its own set of technical challenges, but it will provide a much more comprehensive picture of functional variation.Danielhttp://www.blogger.com/profile/07276690118219000204noreply@blogger.comtag:blogger.com,1999:blog-8480427453110572235.post-82369568182244615362008-04-14T07:30:00.000+10:002008-04-14T07:30:00.000+10:00The fundamental problem with personal genomics is that the hap map is still 99% terra incognita.<BR/><BR/>IQ and height are primarily hereditary, yet we cannot predict either one from the hap map. We have detected a number of genetic areas that are under strong recent selection, and yet can find no phenotype controlled by those haplotypes. In short, we are still in the dark and lost in the woods.James A. Donaldhttp://www.blogger.com/profile/07187941973064976125noreply@blogger.comtag:blogger.com,1999:blog-8480427453110572235.post-17615451290514487932008-04-14T03:00:00.000+10:002008-04-14T03:00:00.000+10:00Hsien,<BR/>If they need any pointers send them my way. The more, the merrier.<BR/>-Steve<BR/>www.helixhealth.orgSteve Murphy MDhttp://www.blogger.com/profile/11774190000307343476noreply@blogger.comtag:blogger.com,1999:blog-8480427453110572235.post-86932876755273935742008-04-14T01:22:00.000+10:002008-04-14T01:22:00.000+10:00Oh No!!! Anna cut my quotes :(<BR/>IMHO in medicine, competition is collaboration. There are 300 million people in the US. Last time I checked....all of them have DNA ;)<BR/><BR/>-Steve<BR/>www.helixhealth.orgSteve Murphy MDhttp://www.blogger.com/profile/11774190000307343476noreply@blogger.comtag:blogger.com,1999:blog-8480427453110572235.post-83703807098205784492008-04-13T23:01:00.000+10:002008-04-13T23:01:00.000+10:00Steve,<BR/><BR/>You don't need to convince me - you need to convince Al Gore...<BR/><BR/>I've downloaded your Future Medicine piece and will hopefully get a chance to digest it soon.<BR/><BR/>Hsien,<BR/><BR/>Thanks for that - I somehow managed to miss that paragraph from the LA Times article (this option certainly hasn't been mentioned much elsewhere). I've updated my post to include it.Danielhttp://www.blogger.com/profile/07276690118219000204noreply@blogger.comtag:blogger.com,1999:blog-8480427453110572235.post-78676556134301251572008-04-13T22:09:00.000+10:002008-04-13T22:09:00.000+10:00Steve, Competition in your niche is coming....Hsien Leihttp://www.blogger.com/profile/07016216779359328550noreply@blogger.comtag:blogger.com,1999:blog-8480427453110572235.post-65226152960126953182008-04-13T22:08:00.000+10:002008-04-13T22:08:00.000+10:00According to Anna Gosline at the <A HREF="http://www.latimes.com/features/health/la-he-genome14apr14,0,2443364.story?page=2" REL="nofollow">LA Times</A>:<BR/><BR/>"Navigenics has taken a more conservative approach. If, for example, I want to get my entire genome scan, which I certainly do, I must sign a waiver acknowledging that any of the SNP-disease associations I might Google myself are likely to be spurious. Only then will the company send me the file on an encrypted disk."Hsien Leihttp://www.blogger.com/profile/07016216779359328550noreply@blogger.comtag:blogger.com,1999:blog-8480427453110572235.post-20170068144905386472008-04-13T21:55:00.000+10:002008-04-13T21:55:00.000+10:00FYI<BR/>http://www.futuremedicine.com/doi/abs/10.2217/17410541.5.2.175<BR/><BR/>-SteveSteve Murphy MDhttp://www.blogger.com/profile/11774190000307343476noreply@blogger.comtag:blogger.com,1999:blog-8480427453110572235.post-85555574038279065732008-04-13T21:32:00.000+10:002008-04-13T21:32:00.000+10:00Daniel,<BR/>We have been doing the same thing at Helix Health. We just aren't throwing the million snp chip at ya! Instead we are taking a family history and truly merging classical and modern genetics with medicine. But we don't have 25 million to throw open bar cocktail parties. Nor do we have any competition...<BR/>-Steve<BR/>www.helixhealth.orgSteve Murphy MDhttp://www.blogger.com/profile/11774190000307343476noreply@blogger.com